The Americans, winners of the last three Olympic titles and the 2015 Women’s World Cup, play world No. 26 Mexico at 4 p.m. ET in Frisco, Texas.
The U.S. is in one of two CONCACAF Olympic qualifying tournament groups with Mexico, Costa Rica (ranked No. 34) and Puerto Rico (No. 108).
The top two teams per group advance to the tournament semifinals, and the Feb. 19 semifinal winners advance to the Rio Games in August.
The U.S. routed Costa Rica 5-0 in its opener on Thursday and, depending on the Costa Rica-Puerto Rico result earlier Saturday, could clinch a semifinal berth with a win over Mexico.
Mexico blanked Puerto Rico 6-0 on Thursday.
The U.S. is heavily favored to qualify for Rio. It is ranked No. 1 in the world, with the next-best North American team ranked No. 11 (Canada, which is in the opposite CONCACAF Olympic qualifying tournament group).
If the U.S. and Canada win their respective groups, they would not have to play each other to qualify for the Olympics.
The U.S. roster for Olympic qualifying includes 13 of the 23 players from the World Cup, led by Olympic champions Carli Lloyd, Alex Morgan and Hope Solo.
All 15 matches of the CONCACAF Olympic qualifying tournament will be streamed live on NBC Sports Live Extra, include four matches on NBCSN.
2016 CONCACAF Women’s Olympic Qualifying Championship Schedule
Frisco, Texas – Toyota Stadium
Houston, Texas – BBVA Compass Stadium
Times U.S. Central (U.S. Eastern in parentheses)
Group A: USA, Puerto Rico, Mexico, Costa Rica
Group B: Canada, Guatemala, Trinidad & Tobago, Guyana
Wednesday, Feb. 10 (Frisco)
Mexico 6, Puerto Rico 0
U.S. 5, Costa Rica 0
Thursday, Feb. 11 (Houston)
Trinidad and Tobago 2, Guatemala 1
Canada 5, Guyana 0
Saturday, Feb. 13 (Frisco)
Costa Rica vs. Puerto Rico 12:30 p.m. (1:30 p.m.)
USA vs. Mexico 3 p.m. (4 p.m.) NBCSN at 9:30 p.m. ET
Sunday, Feb. 14 (Houston)
Guyana vs. Guatemala 12:30 p.m. (1:30 p.m.)
Trinidad vs. Canada 3 p.m. (4 p.m.)
Monday, Feb. 15 (Frisco)
Mexico vs. Costa Rica 5 p.m. (6 p.m.)
USA vs. Puerto Rico 7:30 p.m. (8:30 p.m.) LIVE on NBCSN
Tuesday, Feb. 16 (Houston)
Trinidad & Tobago vs. Guyana 5 p.m. (6 p.m.)
Canada vs. Guatemala 7:30 p.m. (8:30 p.m.)
Friday, Feb. 19 (Houston)
Group B winner vs. Group A runner-up 4:30 p.m. (5:30 p.m.) ***
Group A winner vs. Group B runner-up 7:30 p.m. (8:30 p.m.) ***
Sunday, Feb. 21 (Houston)
Semifinal winners 4 p.m. (5 p.m.) NBCSN at 11 p.m.
***USA’s semifinal, should the USA advance, will air LIVE on NBCSN